Rosetta@home: Help the Fight Against COVID-19 With Your Linux System

Want to contribute to the research on coronavirus? You don’t necessarily have to be a scientist for this. You may contribute with part of your computer’s computing power thanks to Rosetta@home project.

Sounds interesting? Let me share more details on it.

What is Rosetta@home?

Rosetta@home is a distributed computing project for protein structure prediction, based at the Baker laboratory at the University of Washington and running on the Berkeley Open Infrastructure for Network Computing (BOINC) open source platform, which was originally developed to support the SETI@home.

Not enough computing power? Utilize the power of distributed computing

To predict and design the structures of naturally occurring proteins is very computationally intensive. To speed up the process, Dr. David Becker had filled the entire lab and the hallway with desktop computers. Then they started getting complaints of heating up the building, but still didn’t have enough computing power to accurately predict and design protein structures.

How does Rosetta@home work?

Rosetta@home uses idle computer processing power from volunteers’ computers to perform calculations on individual work units. When a requested task is being completed, the client sends the results to a central project server where they are validated and incorporated into project databases.

Rosetta Sharing Example

As of 28th March 2020 the computing power of Rosetta@home has been increased up to 1.7 PetaFlops, due to the recently joined users looking to participate in the fight against the COVID-19 pandemic. Thanks to that, On 26th June 2020, Rosetta@home researchers announced they had created antiviral proteins that neutralized SARS-CoV-2 in the lab.

Is BOINC platform safe?

After few years of operation on millions of systems, there have been no security incidents reported due to BOINC. This fact doesn’t mean that there is no possibility of a security risks.

BOINC uses a mechanism called code signing, based on public-key cryptography, that eliminates the vulnerability, as long as projects use proper practice. Each project has a code-signing key pair consisting of a public key and a private key which is used to create “signatures” for programs. The BOINC client will only run programs with valid signatures.

Projects are instructed to keep the private key only on a computer that is permanently offline to create signatures. Therefore hackers cannot trick BOINC into running malware.

Most BOINC projects follow these practices. If you’re concerned about security, you should attach to a project only if you know it follows the code-signing procedure correctly. If in doubt, you may ask project administrators to describe how they do code signing.

Contributing to Rosetta@home with BOINC platform

Rosetta Home Linux

If you are interested in contributing to the scientific research by donating some computing power, you’ll find rest of this article helpful.

I’ll discuss the following:

  • Prerequisite for joining BOINC platform
  • Using BOINC platform to donate computing power to a project of your choice via your desktop Linux
  • Using Raspberry Pi to run BOINC all the time

System Requirements of the BOINC platform

The BOINC distributed computing platform with which you can access Rosetta@home is available on a 64bit operating system such as Windows, Linux, and macOS and FreeBSD.

You will need a CPU of at least 500 MHz, 200 megabytes of free disk space, 512 megabytes of RAM, and Internet connectivity.

The more CPU cores your system has, the more RAM is required as a work unit will “feed” each core.

Create a user account on BOINC platform

Before you configure the BOINC platform, create an account using your computer. If you will use a Raspberry Pi, you can join the “crunch-on-arm” team.

Please note that the same account can be used to multiple machines at a time. All of your machines will appear on your account.

Install BOINC platform on various Linux distributions

BOINC application has the following element:

  • boinc-client (daemon that runs the platform)
  • boinctui: terminal based interface for selecting projects and other settings
  • boinc-manager: GUI-based interface for selecting projects and other settings

If you are using a server, you should install boinctui. If you are using Linux desktop, you can opt for boinc-manager.

I’ll stick with the GUI tool in this part of the tutorial.

On Debian/Ubuntu

BOINC tools are available in the universe repository in Ubuntu 20.04 so make sure that you have universe repository enabled on your Ubuntu system.

Use the following commands to install it:

sudo apt install boinc-client boinc-manager
Install BOINC on Fedora

Open a terminal and enter the following command:

sudo dnf install boinc-client boinc-manager
Install BOINC on RedHat/CentOS

First, make sure that the EPEL repository is enabled, by running following command on a terminal:

sudo yum install epel-release

You can now install the necessary packages:

sudo yum install boinc-client boinc-manager

Open the BOINC manager and add a project

After installing, open BOINC manager. You will be asked to add a project and to create an account or login to an existing.

Boinc Manager

Add your credentials and click finish when prompted.

Boinc Credentials

After a few minutes, the status will change to running.

Boinc Manager Running

You don’t need to worry if your system resources will be consumed when you want to use your computer. By default, if the BOINC manager notices that the user needs more than the 25% of CPU resources, the BOINC computation will be suspended.

If you want the application to be suspended at a lower or higher CPU usage, you can change your profile settings on the website where you created your account.

Rosetta@home on a Raspberry Pi 4

An ideal device to run 24/7 the Rosetta@home application is a Raspberry Pi, which is powerful enough and with very low power consumption.

To fight COVID-19 using a Raspberry Pi 4, you need a model with 2 GB RAM or more. My personal recommendation is the 4 GB RAM option, because with my 2 GB model one of the cores is idling as it is running out of memory.

Step 1: Install Ubuntu Server (Recommended)

You need to have some operating system on your Raspberry Pi. Installing Ubuntu server on Raspberry Pi is one of the most convenient choices.

Step 2: Install BOINC platform

To install the BOINC client and the command line management interface run the following command on server running on the Raspberry Pi.

sudo apt install boinc-client boinctui
Additional steps for Raspberry Pi 2 GB model

Your account by default is set to utilize 90% of the memory when the user is idling. The Rosetta work units require 1.9gb of memory to run on the Quad core Raspberry Pi, so there is a possibility for the client not be able to start due to the initial reading. If the Raspberry Pi runs out of memory, it will suspend one of the 4 running tasks as mentioned earlier. To override the 1.9gb threshold add the following lines to the location below:

sudo nano /var/lib/boinc-client/global_prefs_override.xml

Add now these lines

Rosetta Settings Local Override

This setting will increase the default memory available to Rosetta to the maximum amount of memory on the board.

Step 3: Add Rosetta@home project

On your Raspberry Pi command line type ‘boinctui’ and click enter to load the terminal GUI. 


Press F9 on the keyboard, to bring down the menu choices. Use the arrow keys to go to Projects and press Enter.

You may notice a few available projects to choose from but if you are interested to actively support the fight against COVID-19 choose Rosetta. You will be prompted to either create a user account or to use an existing account.

Select “Existing User” and the enter the credentials you created on the website at the initial step.  As you can see, I have already selected the Rosetta project.

Rosetta Add Project

It will take a moment to download the work units, and then automatically it will start crunching data on your Raspberry Pi 4!


If you want to stop using BOINC, simply delete the boinc packages you installed earlier. I believe you know how to use your distribution’s package manager for removing software.

One of the benefits of distributing computing is to allow user’s to donate their system resources for the common good. Despite the grief the pandemic has spread worldwide, it can make us also to realize the necessity of volunteering in one way or the other.

If you ever wondered about a good use of your Raspberry Pi, Rosetta@home can be included to the list.

Let us know at the comments below if you started “cruching” and which platform you chose. Stay safe!

About the author


Dimitrios is an MSc Mechanical Engineer but a Linux enthusiast in heart. His machines are powered by Arch Linux but curiosity drives him to constantly test other distros. Challenge is part of his per


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